Have any of you have tried Metformin or know anything about its use to treat idiopathic edema/increased cellular permeability? I came across two studies that found it very successful for people with IE and the majority of patients achieved a complete response. I have an appointment with Dr. Check in a few weeks and will ask him about it.
The Effects of Metformin on the Capillary Permeability to Albumin in Women Patients with Cyclic Edema (1995)
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.882.5963&rep=rep1&type=pdf
Long term use of metformin in idiopathic cyclic edema, report of thirteen cases and review of the literature (2017)
https://www.ncbi.nlm.nih.gov/pubmed/28212888
It looks like the insurance company will pay for Vyvanse 10mg once a day instead of 30mg a day. We will know for sure this week. I am lucky that I don't need more than that normally since I am very sensitive to medication. The problem may arise when I am not in remission and need to increase the dosage. I looked a bit more into Metformin but it causes some gastroparesis in the way it works in the body. This is not good for me as my main symptom is first Gastroparesis then the fluid. If you don't suffer from gastroparesis, it may be something you could try. Just make sure you have regular ongoing medical checks with blood work, kidney function and such. That is my latest update so we will see how this plays out.