When last I wrote I was able to keep doing my daily activities but as the edema worsens, I find myself staying close to home as I am short of breath at times. My GI activity has slowed down considerably so I have to curtail my normal activities. I should have increased dose today as it is raining. The big shifts in the weather do a number on my muscles and joints as well. I personally can't take more medication now that it is after 3 p.m. as it keeps me up at night. Most people don't have this problem however. We are all different with the medication and timing and have to find what is right for us. Tomorrow and next three days supposed to be sunny and temperature stable so it should improve again. I need to remember to split the dose and actually take the second dose of the medication (for me before one o'clock. Taking it on a full stomach helps with having anxiety which can be debilitating too. I do well with it after breakfast.